Healing spray can be incredibly useful if the player has a lack of skilled medics in their party; survivors with low medical skill can use up to four medical supplies for one hit point healed. Healing spray, on the other hand, can save up to 12 medical supplies in that instance. Examples of ideal use include during trader camp visits where there is a lack of danger, or oppositely, when a teammate is damaged in a siege or dangerous scavenging mission and might not make it at less than full health.
- Due to a bug, healing spray can currently be used to revive dead teammates while looting, as long as they have not been bitten after getting killed.
- This is because healing spray will always increase a character's health by 1, regardless of whether that character is dead or alive; if a character has just been killed, their health will be at 0, and the use of an Ouchie Spray will bring their health back up to 1 again, reviving them.